TCS 401

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TCS 401 是蛋白质酪氨酸磷酸酶 1B (PTP1B；Ki = 0.29 μM) 的选择性抑制剂。

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 μM).

TCS-401 (0.5, 1, 2?μM) significantly increases the proliferation of RPE cells. TCS-401 significantly increases the expression of cyclin A and cyclin D1 at the concentrations of 1 and 2 μM in a concentration-dependent manner. TCS-401 at concentrations of 0.5, 1, and 2 μM significantly increases phosphorylation of Erk and Akt compared to the control group. The activation of Erk and Akt by TCS-401 is blocked by pretreatment with PD98059 and LY294002, respectively. CS-401 treatment activates the MEK/Erk and PI3K/Akt signaling pathways and induces proliferation, differentiation, and migration in RPE cells. CS-401 dose dependently inhibits the RPTC-Sup-induced reduction of fibronectin and α-SMA. At 1 μM, TCS-401 reverses the levels of fibronectin and α-SMA about onefold and at a dose of 2 μM, TCS-401 brings back fibronectin and α-SMA expression to near normal levels.

——

——

Metabolic Enzyme/Protease

Phosphatase

PTP1B

——

——

243966-09-8

306.72

C10H11ClN2O5S

>98% (HPLC)

DMSO:11 mg/mL (35.86 mM)

Cl.OC(=O)C(=O)Nc1sc2CNCCc2c1C(O)=O

2-(Oxaloamino)-4567-tetrahydrothieno[23-c]pyridine-3-carboxylic acid hydrochloride

(-20℃)

With Ice Pack

≥ 2 years